Vanderbilt University investigators have discovered that in mice, a probiotic bacteria produces a therapeutic compound that prevents some of the adverse effects of a high fat diet such as weight gain and insulin resistance.
"The types of bacteria you have in your gut influence your risk for chronic diseases," said senior investigator Sean Davies, but it may be possible to manipulate the bacterial residents of the gut (microbiota) to treat obesity and other chronic diseases.
The team genetically engineered the E. coli Nissle stain to produce a compound known as NAPE that reduces both food intake and weight gain.
The investigators observed that the experimental group of mice that were exposed to NAPE-producing bacteria in their drinking water had dramatically lower food intake, body fat, insulin resistance, and fatty liver compared to mice receiving control bacteria.
The ultimate goal for this team is to do one treatment and then never have to administer the bacteria again. Thanks to their research, a probiotic that prevents obesity could be in reach.
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